Research

The Thrombosis and Hemostasis Program is dedicated to bringing the  highest quality of care to our patients.  As part of that mission, we have active clinical and laboratory research programs at Fletcher Allen Health Care and the University of Vermont.  In addition, we collaborate with scientists and physicians from around the world to move science forward, make new discoveries and find new treatments for patients with clotting and bleeding problems. Clinical trials are open to patients who wish to participate and meet set entry criteria.  At the link, clinical trials you can find information on studies that are currently open for participation.  If you would like more information on participating in any of these trials, please contact us via our information email THP@vtmednet.org.
 
We have many ongoing research studies designed to improve our understanding of clotting and bleeding.  At our link, Research Studies you will find information on active research studies in our Laboratories.  Some of these studies have participants from around the country and around the world but are not currently open for enrollment in Vermont. 

 

Research Studies

Laboratory for Clinical Biochemistry Research:
This laboratory is on the UVM research campus in Colchester, VT and is where most of our research takes place. The lab's focus is on understanding risk factors and causes for heart disease, stroke, venous thrombosis, obesity, diabetes, aging, cognitive disorders and frailty using a wide variety of assays in population and family-based research settings, particularly in the areas of coagulation, fibrinolysis, thrombosis, inflammation, and immune system function.
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Leducq International Network Against Thrombosis (LINAT): 
This research network includes teams from Europe and the United States, focused on advancing our knowledge on the causes of vascular disease.
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Cardiovascular Health Study (CHS): 
Purpose:  studying risk factors and clinical course of diseases of aging in those aged 65+. Focus is on vascular diseases and cognitive function. Our group studies the biology of these diseases by measuring risk factors in blood samples.
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Longitudinal Investigation of Thromboembolism Etiology (LITE):
Studying risk factors for deep vein thrombosis and pulmonary embolism in over 20,000 people.
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REasons for Geographic and Racial Differences in Stroke (REGARDS):
We are studying causes of stroke to understand why people in some parts of the country develop more strokes than people in other parts of the country, and why African-Americans develop more strokes than whites. We are interested in factors such as blood pressure, cholesterol, diet and other factors and how they are related to the risk of stroke. We hope to learn how to reduce the number of people having strokes.
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San Diego Population Study:
We are working on understanding why people develop venous insufficiency, a condition that causes leg problems.
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Multiethnic Study of Atherosclerosis (MESA):
Purpose:  Studying risk factors for the progression of atherosclerosis (hardening of the arteries) or the change of atherosclerosis to clinically manifest vascular disease.
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Women’s Health Initiative (WHI):
We collaborate with researchers in the Women’s Health Initiative to understand why menopausal hormone treatments have health risks and benefits.
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