ponatinib

Pronunciation: poe NA ti nib

Brand: Iclusig

What is the most important information I should know about ponatinib?

Multum donot

You should not use ponatinib if you are allergic to it.

Before you take ponatinib, tell your doctor if you have heart disease, high blood pressure, a history of stroke or blood clot, liver disease, a bleeding disorder, a history of pancreatitis, or a history of stomach or intestinal bleeding.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ponatinib.

Grapefruit and grapefruit juice may interact with ponatinib and lead to unwanted side effects. Avoid drinking grapefruit juice while taking this medication.

You may need frequent medical tests at your doctor's office to be sure this medication is not causing harmful effects. If you need surgery, tell the surgeon ahead of time that you are using ponatinib. You may need to stop using the medicine for a short time. Do not stop taking ponatinib or change your medication dose without your doctor's advice.

Multum calldoc

Call your doctor at once if you have chest pain spreading to your arm or shoulder, sudden numbness or weakness, problems with vision or speech, warmth or pain in one or both legs, easy bruising, unusual bleeding, blood in your urine or stools, fever, flu symptoms, mouth sores, upper stomach pain, dark urine, jaundice (yellowing of the skin or eyes), lower back pain, severe headache, buzzing in your ears, or feeling like you might pass out.

What is ponatinib?

Ponatinib interferes with the growth of some cancer cells.

Ponatinib is used to treat a type of blood cancer called chronic myeloid leukemia (CML), or Philadelphia chromosome positive acute lymphoblastic leukemia (ALL).

Ponatinib is usually given after other similar medications have been tried without success.

Ponatinib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ponatinib?

Multum donot

You should not use ponatinib if you are allergic to it.

To make sure ponatinib is safe for you, tell your doctor if you have:

  • heart disease, high blood pressure;
  • a history of stroke or blood clot;
  • liver disease;
  • a bleeding or blood-clotting disorder;
  • a history of pancreatitis; or
  • a history of stomach or intestinal bleeding.
Multum nopreg

FDA pregnancy category D. Do not use ponatinib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Multum nobrfeed

It is not known whether ponatinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Multum nochild

Do not give this medication to anyone under 18 years old without medical advice.

How should I take ponatinib?

Ponatinib is usually taken once daily. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take ponatinib with or without food.

Multum nocrush

Do not crush, break, or dissolve a ponatinib tablet. Swallow it whole.

Do not share this medication with another person, even if they have the same symptoms you have.

Multum emt

You may need frequent medical tests at your doctor's office to be sure this medication is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests.

If you need surgery, tell the surgeon ahead of time that you are using ponatinib. You may need to stop using the medicine for a short time.

Do not stop taking ponatinib or change your medication dose without your doctor's advice.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking ponatinib?

Multum donot

Grapefruit and grapefruit juice may interact with ponatinib and lead to unwanted side effects. Avoid drinking grapefruit juice while taking this medication.

What are the possible side effects of ponatinib?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, sweating, general ill feeling;
  • sudden numbness or weakness (especially on one side of the body), problems with vision, speech, or balance;
  • sudden cough, wheezing, rapid breathing, coughing up blood;
  • pain, swelling, warmth, or redness in one or both legs;
  • bloody or tarry stools, pink or brown urine;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • heavy menstrual periods;
  • pale skin, confusion, severe drowsiness, feeling like you might pass out;
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • uneven or irregular heart rate;
  • feeling short of breath (even with mild exertion), swelling, rapid weight gain;
  • itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • severe pain in your upper stomach spreading to your back, nausea and vomiting;
  • lower back pain, blood in your urine, little or no urinating, numbness or tingly feeling around your mouth, muscle weakness, tightness, or contraction, overactive reflexes, weak pulse, fainting; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, seizure).

Common side effects may include:

  • dry skin, mild skin rash;
  • stomach pain, constipation;
  • headache, tired feeling; or
  • joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ponatinib?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ponatinib, especially:

  • conivaptan;
  • imatinib;
  • isoniazid;
  • nefazodone;
  • heart or blood pressure medicine--nicardipine, quinidine;
  • an antibiotic--clarithromycin, telithromycin;
  • antifungal medicine--itraconazole, ketoconazole, posaconazole, voriconazole;
  • the hepatitis C medications boceprevir or telaprevir; or
  • HIV or AIDS medications--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.

This list is not complete. Other drugs may interact with ponatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about ponatinib.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 1.01. Revision date: 2/14/2013.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.