axitinib

Pronunciation: axIT i nib

Brand: Inlyta

What is the most important information I should know about axitinib?

Multum nopreg

Do not use axitinib if you are pregnant. It could harm the unborn baby. Use birth control to prevent pregnancy while you are receiving axitinib, whether you are a man or a woman. Axitinib use by either parent may cause birth defects or miscarriage.

Multum donot

You should not use axitinib if you are allergic to it.

Before you take axitinib, tell your doctor if you have liver or kidney disease, high blood pressure, a thyroid disorder, bleeding problems, an unhealed wound, stomach or intestinal bleeding, or a history of brain tumor, stroke, or blood clot.

Axitinib is usually taken once every 12 hours. Axitinib should be taken at evenly spaced intervals. Follow your doctor's instructions.

Multum emt

To be sure this medication is not causing harmful effects, your kidney, thyroid, and liver function will need to be tested. Your blood pressure will also need to be checked often. Visit your doctor regularly.

Multum emt

If you need surgery, tell the surgeon ahead of time that you are using axitinib. You may need to stop using the medicine for a short time.

Multum donot

Stop using axitinib and call your doctor at once if you have sudden weight loss, vision problems, confusion, sudden numbness or weakness, severe headache, feeling hot or cold, severe stomach pain, unusual bleeding, or seizure (convulsions).

What is axitinib?

Axitinib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Axitinib is used to treat cancer of the kidney.

Axitinib is usually given after other cancer medication has been tried without successful treatment.

Axitinib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking axitinib?

Multum donot

You should not use axitinib if you are allergic to it.

To make sure you can safely use axitinib, tell your doctor if you have any of these other conditions:

  • liver disease;
  • kidney disease;
  • high blood pressure;
  • a thyroid disorder;
  • bleeding problems, or a wound that has not healed;
  • recent stomach or intestinal bleeding;
  • history of perforation (a hole or tear) in your stomach or intestines;
  • history of a brain tumor; or
  • a history of stroke or blood clot.
Multum nopreg

FDA pregnancy category D. Do not use axitinib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Use birth control to prevent pregnancy while you are receiving axitinib, whether you are a man or a woman. Axitinib use by either parent may cause birth defects or miscarriage.

Multum nobrfeed

It is not known whether axitinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using axitinib.

How should I take axitinib?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Axitinib is usually taken once every 12 hours. Follow your doctor's instructions.

Axitinib should be taken at evenly spaced intervals. You may take axitinib with or without food.

Multum water

Take this medicine with a full glass of water.

Your blood pressure will need to be checked often. Visit your doctor regularly.

Multum emt

To be sure this medication is not causing harmful effects, your kidney, thyroid, and liver function will need to be tested. Your cancer treatments may be delayed based on the results of these tests. Do not miss any follow up visits to your doctor for blood or urine tests.

Multum emt

If you need surgery, tell the surgeon ahead of time that you are using axitinib. You may need to stop using the medicine for a short time.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include seizure (convulsions).

What should I avoid while taking axitinib?

Grapefruit and grapefruit juice may interact with axitinib and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

What are the possible side effects of axitinib?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using axitinib and call your doctor at once if you have a serious side effect such as:

  • sudden numbness or weakness, problems with speech or balance;
  • pain, swelling, warmth, or redness in one or both legs;
  • severe headache, confusion, change in mental status, vision loss, and/or seizure (convulsions);
  • severe stomach pain;
  • red or pink urine, bloody or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;
  • any wound that will not heal;
  • sudden weight loss, increased appetite, pounding heartbeats, fluttering in your chest, feeling very weak or tired, muscle pain, numbness or tingling in your hands, dry skin and hair, feeling hot or cold, changes in your menstrual periods, hoarse voice, swelling in your neck or throat (enlarged thyroid); or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats).

Less serious side effects may include:

  • nausea, vomiting;
  • diarrhea, constipation; or
  • loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect axitinib?

Tell your doctor about all other medicines you use, especially:

  • boceprevir (Victrelis);
  • bosentan (Tracleer);
  • conivaptan (Vaprisol);
  • dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
  • imatinib (Gleevec);
  • isoniazid (for treating tuberculosis);
  • nefazodone;
  • St. John's wort;
  • theophylline (Elixophyllin, Theochron, Uniphyl);
  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);
  • antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
  • heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G);
  • HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), saquinavir (Invirase), or telaprevir (Incivek);
  • medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil); or
  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

There may be other drugs that can interact with axitinib. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about axitinib.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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