chlophedianol, guaifenesin, and pseudoephedrine

Pronunciation: KLOE fe DYE a nol, gwye FEN e sin, SOO doe ee FED rin

Brand: Vanacof DX

What is the most important information I should know about chlophedianol, guaifenesin, and pseudoephedrine?

Multum nochild

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Multum emt

Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as high blood pressure, heart disease, coronary artery disease, or a thyroid disorder.

Multum donot

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

What is chlophedianol, guaifenesin, and pseudoephedrine?

Chlophedianol is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlophedianol, guaifenesin, and pseudoephedrine is used to treat stuffy nose, cough, chest congestion, and sinus congestion caused by allergies, the common cold, or the flu.

Multum smoking

Chlophedianol, guaifenesin, and pseudoephedrine will not treat a cough that is caused by smoking, asthma, or emphysema.

Chlophedianol, guaifenesin, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking chlophedianol, guaifenesin, and pseudoephedrine?

Multum donot

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Multum emt

Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as high blood pressure, heart disease, coronary artery disease, or a thyroid disorder.

To make sure you can safely use this medicine, tell your doctor if you have any of these other conditions:

  • diabetes;
  • epilepsy or other seizure disorder;
  • cough with mucus, or cough caused by emphysema, or chronic bronchitis;
  • enlarged prostate or urination problems; or
  • pheochromocytoma (an adrenal gland tumor).
Multum nopreg

It is not known whether chlophedianol, guaifenesin, and pseudoephedrine will harm an unborn baby. Do not use cough or cold medicine without telling your doctor if you are pregnant or plan to become pregnant while using the medicine.

Multum nobrfeed

Chlophedianol, guaifenesin, and pseudoephedrine may pass into breast milk and may harm a nursing baby. Decongestants may also slow breast milk production. Do not use cough or cold medicine without telling your doctor if you are breast-feeding a baby.

How should I take chlophedianol, guaifenesin, and pseudoephedrine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

Multum nochild

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Multum emt

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days.

Multum rt

Store at room temperature away from moisture and heat. Do not freeze.

What happens if I miss a dose?

Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking chlophedianol, guaifenesin, and pseudoephedrine?

Multum dizzy

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Multum noalcohol

Drinking alcohol can increase certain side effects of chlophedianol, guaifenesin, and pseudoephedrine.

Multum donot

Ask a doctor or pharmacist before using any other cold, allergy, or cough medicine. Antitussives, expectorants, and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antitussive, expectorant, or decongestant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

What are the possible side effects of chlophedianol, guaifenesin, and pseudoephedrine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using chlophedianol, guaifenesin, and pseudoephedrine and call your doctor at once if you have a serious side effect such as:

  • fast, slow, or uneven heart rate;
  • severe dizziness or anxiety, feeling like you might pass out;
  • mood changes, hallucinations;
  • severe headache;
  • tremor, seizure (convulsions);
  • fever; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, uneven heartbeats, seizure).

Less serious side effects may include:

  • mild dizziness or drowsiness;
  • mild headache;
  • diarrhea, constipation, nausea, upset stomach;
  • sleep problems (insomnia); or
  • feeling nervous or restless.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlophedianol, guaifenesin, and pseudoephedrine?

Multum dizzy

Before using chlophedianol, guaifenesin, and pseudoephedrine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlophedianol or guaifenesin.

There may be other drugs that can interact with chlophedianol, guaifenesin, and pseudoephedrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about chlophedianol, guaifenesin, and pseudoephedrine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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