posaconazole

Pronunciation: poe sa KONE a zole

Brand: Noxafil

What is the most important information I should know about posaconazole?

Multum donot

You should not take posaconazole together with: atorvastatin, lovastatin, simvastatin, pimozide, quinidine, sirolimus, or an ergot medicine (dihydroergotamine, ergotamine, ergonovine, or methylergonovine).

What is posaconazole?

Posaconazole is an antifungal medication that fights certain infections caused by fungus.

Posaconazole is used to prevent fungal infections in people with weak immune systems resulting from certain treatments or conditions (such as chemotherapy, stem cell transplantation, HIV infection, and others).

Posaconazole is also used to treat oral thrush (yeast infection of the mouth).

Posaconazole may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using posaconazole?

Multum donot

You should not use this medication if you are allergic to posaconazole or similar antifungals such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig, Monistat), voriconazole (Vfend), and others.

Many drugs can interact with posaconazole and some should not be used at the same time, especially:

  • pimozide;
  • quinidine;
  • sirolimus;
  • cholesterol lowering medicines --atorvastatin (Lipitor), lovastatin (Mevacor), or simvastatin (Zocor, Vytorin); or
  • ergot medicine --dihydroergotamine, ergotamine, ergonovine, or methylergonovine.

To make sure posaconazole is safe for you, tell your doctor if you have:

  • a heart rhythm disorder;
  • a personal or family history of Long QT syndrome;
  • liver or kidney disease; or
  • if you take medicine to prevent organ transplant rejection (cyclosporine, tacrolimus).
Multum nopreg

FDA pregnancy category C. It is not known whether posaconazole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether posaconazole passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using posaconazole.

Multum nochild

Do not give this medication to a child younger than 13 years old.

How should I take posaconazole?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Multum nocrush

Do not crush, chew, dissolve, or break a delayed-release tablet. Swallow it whole.

Multum shake

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Multum food

Posaconazole delayed-release tablet works best if you take it with food. Take the oral suspension within 20 minutes after a full meal. If you cannot eat a full meal, take the oral suspension with a nutritional supplement (such as BOOST) or with an acidic carbonated drink such as ginger ale.

Multum emt

Call your doctor if you have ongoing vomiting or diarrhea. Posaconazole may not work as well while during this time.

While using posaconazole, you may need frequent blood tests.

Multum finish

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Posaconazole will not treat a viral infection such as the common cold or flu.

Multum rt

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking posaconazole?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of posaconazole?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • pale skin, easy bruising or bleeding, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • signs of an infection --fever, chills, sore throat, flu symptoms, vomiting, mouth sores;
  • liver problems --nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low potassium --confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling.

Common side effects may include:

  • diarrhea, nausea, vomiting;
  • mild headache;
  • fever; or
  • cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect posaconazole?

Many drugs can interact with posaconazole. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with posaconazole, especially:

  • cimetidine, esomeprazole;
  • citalopram;
  • midazolam;
  • nimodipine;
  • phenytoin;
  • rifabutin;
  • anti-malaria medication --artemether, lumefantrine;
  • cancer medicine --arsenic trioxide, bosutinib, nilotinib, toremifene, vandetanib, vemurafenib, vinblastine, vincristine, vinorelbine;
  • heart rhythm medicine --amiodarone, dofetilide, dronedarone, procainamide, sotalol;
  • HIV or AIDS medication --atazanavir, efavirenz, fosamprenavir, ritonavir; or
  • medicine to treat a psychiatric disorder --iloperidone, thioridazine, ziprasidone, others.

This list is not complete and many other drugs can interact with posaconazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about posaconazole.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 4.02. Revision date: 12/30/2013.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.