sildenafil (injection)

Pronunciation: sil DEN a fil

Brand: Revatio

What is the most important information I should know about injectable sildenafil?

Multum donot

Do not use sildenafil injection if you are also taking a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Using sildenafil injection with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

Multum donot

Do not use sildenafil injection with Viagra similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra). Tell your doctor about all medications you use for erectile dysfunction.

Multum emt

Get emergency medical help if you have ringing in your ears, sudden hearing loss, or sudden vision loss.

What is sildenafil?

Sildenafil relaxes muscles and increases blood flow to particular areas of the body, including the lungs.

Sildenafil injection (Revatio) is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.

Another brand of sildenafil is Viagra, which is used to treat erectile dysfunction (impotence) in men. Revatio is used to treat PAH in both men and women.

Multum donot

Do not use sildenafil injection while also taking Viagra or other erectile dysfunction medications, unless your doctor tells you to.

Sildenafil injection may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using injectable sildenafil?

Multum donot

Do not use sildenafil injection if you are also taking a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Using sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

Multum donot

You should not use sildenafil injection if you are allergic to it.

To make sure this medicine is safe for you, tell your doctor if you have:

  • heart disease or heart rhythm problems, angina (chest pain), coronary artery disease, circulation problems;
  • a condition called pulmonary veno-occlusive disease;
  • a recent history (in the past 6 months) of a heart attack, stroke, or congestive heart failure;
  • high or low blood pressure;
  • liver or kidney disease;
  • a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;
  • a bleeding disorder such as hemophilia;
  • a stomach ulcer;
  • retinitis pigmentosa (an inherited condition of the eye), or a history of vision loss;
  • a physical deformity of the penis (such as Peyronie's disease).
Multum emt

Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people using sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old. It is not clear whether sildenafil is the actual cause of vision loss.

FDA pregnancy category B. Sildenafil is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Multum nobrfeed

It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Multum nochild

Do not give this medication to anyone under 18 years old without medical advice.

How should I use injectable sildenafil?

This medicine is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject sildenafil if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Sildenafil injection is usually given three times each day. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

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Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. These conditions may cause very low blood pressure. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

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Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using injectable sildenafil?

Multum donot

Avoid using other medicines to treat impotence without your doctor's advice.

What are the possible side effects of injectable sildenafil?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • sudden vision loss;
  • ringing in your ears, or sudden hearing loss;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • irregular heartbeat;
  • swelling in your hands, ankles, or feet;
  • shortness of breath;
  • vision changes;
  • a light-headed feeling, like you might pass out; or
  • penis erection that is painful or lasts 4 hours or longer.

Common side effects may include:

  • nosebleed;
  • headache;
  • upset stomach;
  • flushing (warmth, redness, or tingly feeling);
  • sleep problems (insomnia); or
  • runny or stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect injectable sildenafil?

Multum donot

Do not use Revatio with Viagra similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra). Tell your doctor about all medications you use for erectile dysfunction.

Many drugs can interact with sildenafil. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with sildenafil, especially:

  • an antibiotic such as clarithromycin, erythromycin, rifampin, or telithromycin;
  • antifungal medication such as itraconazole, ketoconazole, miconazole, posaconazole, or voriconazole;
  • drugs to treat high blood pressure or a prostate disorder, such as alfuzosin, doxazosin, prazosin, terazosin, silodosin, tamsulosin;
  • heart or blood pressure medication such as amlodipine, diltiazem, nicardipine, quinidine, or verapamil;
  • the hepatitis C medications boceprevir or telaprevir; or
  • HIV/AIDS medicine such as atazanavir, darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, or tipranavir.

This list is not complete and many other drugs can interact with sildenafil. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about sildenafil injection.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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