hydrochlorothiazide and enalapril

Pronunciation: HYE droe KLOR oh THYE a zide and en AL e pril

Brand: Vaseretic 10-25, Vaseretic 5-12.5

Enalapril-HCTZ-5mg-12.5mg-TAR

oblong, white, imprinted with T4

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Enalapril-HCTZ 10 mg-25 mg-MYL

round, white, imprinted with M, 712

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Enalapril-HCTZ 10-25 mg-APO

round, brown, imprinted with APO, 10 25

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Enalapril-HCTZ 5-12.5 mg-APO

round, brown, imprinted with APO, 5 12.5

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Enalapril-HCT 10 mg-25 mg-MYL

round, white, imprinted with 723, M

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Enalapril-HCTZ 5 mg-12.5 mg-TEV

oblong, white, imprinted with 93, 1044

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Enalapril-HCTZ 10 mg-25 mg-TEV

oblong, brown, imprinted with 93, 1052

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Vaseretic 10-25

hexagonal, pink, imprinted with VASERETIC, MSD 720

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What is the most important information I should know about hydrochlorothiazide and enalapril?

If you have diabetes, do not use hydrochlorothiazide and enalapril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

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Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant.

What is hydrochlorothiazide and enalapril?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Enalapril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Enalapril lowers blood pressure and also relieves symptoms of fluid retention.

Hydrochlorothiazide and enalapril is a combination medicine used to treat hypertension (high blood pressure).

Hydrochlorothiazide and enalapril may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking hydrochlorothiazide and enalapril?

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You should not use this medication if you are allergic to hydrochlorothiazide or enalapril, or if:

  • you are unable to urinate; or
  • you are allergic to any other ACE inhibitor, such as benazepril, captopril, fosinopril, lisinopril, quinapril, ramipril, trandolapril, and others.

If you have diabetes, do not use hydrochlorothiazide and enalapril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

You may also need to avoid taking hydrochlorothiazide and enalapril with aliskiren if you have kidney disease.

To make sure hydrochlorothiazide and enalapril is safe for you, tell your doctor if you have:

  • kidney disease (or if you are on dialysis);
  • liver disease;
  • glaucoma;
  • congestive heart failure;
  • gout;
  • lupus;
  • diabetes; or
  • an allergy to sulfa drugs or penicillin.
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FDA pregnancy category D. Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Hydrochlorothiazide and enalapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.

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Hydrochlorothiazide and enalapril can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How should I take hydrochlorothiazide and enalapril?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and enalapril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and enalapril. You may need to stop using the medicine for a short time.

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Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking hydrochlorothiazide and enalapril?

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

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Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Multum noalcohol

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and enalapril.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and enalapril, unless your doctor has told you to.

What are the possible side effects of hydrochlorothiazide and enalapril?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • chest pain;
  • eye pain, vision problems;
  • pale skin, easy bruising or bleeding;
  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, trouble swallowing;
  • high potassium --slow heart rate, weak pulse, muscle weakness, tingly feeling;
  • low potassium --confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling;
  • low levels of sodium --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or
  • severe skin reaction --fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • headache, dizziness;
  • cough;
  • weakness, tired feeling;
  • nausea, diarrhea; or
  • muscle cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrochlorothiazide and enalapril?

Other drugs may interact with hydrochlorothiazide and enalapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and enalapril.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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