dantrolene (oral)

Pronunciation: DAN troe leen

Brand: Dantrium

Dantrolene 25 mg-GLO

capsule, green/yellow, imprinted with G441

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Dantrium 25 mg

orange/peach, imprinted with DANTRIUM 25 mg, 0149 0030

Image of Dantrium 25 mg
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Dantrolene 100 mg-GLO

capsule, red/yellow, imprinted with G443

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Dantrolene 50 mg-GLO

capsule, blue/yellow, imprinted with G442

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What is the most important information I should know about dantrolene?

Multum donot

You should not use dantrolene if you have liver disease such as hepatitis or cirrhosis. Do not use dantrolene at a time when muscle tone is needed to assure safe balance and movement for certain activities.

Multum emt

Dantrolene can cause life-threatening liver damage, especially if you take high doses or take the medicine long-term. You may be more likely to develop liver problems while taking dantrolene if you are a woman, if you are older than 35, or if you also take other medications. Ask your doctor about your individual risk.

Multum calldoc

Call your doctor at once if you have signs of liver problems --nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These side effects may be most likely to occur between 3 and 12 months of your treatment with dantrolene.

While using dantrolene, you may need frequent blood tests to check your liver function.

What is dantrolene?

Dantrolene is a muscle relaxant.

Dantrolene is used to treat muscle spasticity (stiffness and spasms) caused by conditions such as a spinal cord injury, stroke, cerebral palsy, or multiple sclerosis.

Dantrolene is also used to prevent muscle stiffness and spasms caused by malignant hyperthermia (a rapid rise in body temperature) that can occur during surgery with certain types of anesthesia.

Dantrolene may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking dantrolene?

Multum donot

You should not take this medicine if you are allergic to dantrolene, or if you have liver disease such as hepatitis or cirrhosis. Do not use dantrolene at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

Multum emt

Dantrolene can cause life-threatening liver damage, especially if you take high doses or take the medicine long-term. You may be more likely to develop liver problems while taking dantrolene if you are a woman, if you are older than 35, or if you also take other medications. Ask your doctor about your individual risk.

To make sure dantrolene is safe for you, tell your doctor if you have:

  • a history of liver disease;
  • a breathing disorder such as COPD (chronic obstructive pulmonary disease); or
  • heart disease, or a history of heart attack.
Multum nopreg

FDA pregnancy category C. It is not known whether dantrolene will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

Dantrolene can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Multum nochild

Dantrolene should not be given to a child younger than 5 years old.

How should I take dantrolene?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using dantrolene.

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Multum water

Take this medicine with a full glass of water. If you take dantrolene within 3 or 4 hours before surgery, use only enough water needed to swallow the pill.

While using dantrolene, you may need frequent blood tests to check your liver function.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking dantrolene?

Multum dizzy

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Multum noalcohol

Drinking alcohol can increase certain side effects of dantrolene.

Multum nosun

Avoid exposure to sunlight or tanning beds. Dantrolene can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of dantrolene?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have signs of liver problems --nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These side effects may be most likely to occur between 3 and 12 months of your treatment with dantrolene.

Multum donot

Dantrolene can cause muscle weakness, which can affect your ability to swallow. Use caution to prevent choking while you are eating meals. Talk with your doctor if you are unable to eat because of this side effect.

Multum calldoc

Also call your doctor right away if you have:

  • muscle weakness;
  • severe drowsiness; or
  • vomiting, severe diarrhea.

Common side effects may include:

  • mild diarrhea;
  • weakness, drowsiness;
  • dizziness; or
  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dantrolene?

Multum dizzy

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking dantrolene with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with dantrolene, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about dantrolene.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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