Echocardiography & Magnetic Resonance Imaging

Research in the Echocardiography Laboratory and Cardiac Magnetic Resonance (CMR) Suite has focused on the natural history and pathophysiology of mitral regurgitation and the differential effects of mitral valve repair and replacement surgeries.  We have also elucidated effects of alteration in ventricular geometry on exercise performance and ventricular filling in patients with congestive heart failure, and have been quantifying the extent of myocardial infarction, determinants of favorable responses to resynchroni-zation therapy, and regional myocardial viability.

Active collaborations exist with Dr. Philip Ades studying the effects of resistance training in elderly patients with coronary disease and with Dr. Martin LeWinter in his studies of left ventricular restoring forces.

Representative Publications

Ades, P, Savage P, Tischler M, Poehlman E, Dee J, Niggel J.  Determinants of disability in older coronary patients. Am Heart J 2002:  143(1):151-156.

Bell S, Nyland L, Tischler M, McNabb M, Grnzier H, LeWinter M.  Alterations in the determinants of diastolic suction during pacing tachycardia. Circ Res 2000; 87: 235-240.

Tischler M, Rowan M, LeWinter M.  Effect of enalapril therapy on left ventricular mass and volumes in compensated chronic, severe mitral regurgitation. Am J Cardiol 1998; 82:242-246.

Rothfeld J, LeWinter M, Tischler M. Left ventricular systolic torsion and early diastolic filling: an echocardiographic study in normal humans. Am J Cardiol 1998;81:1465-9.

Tischler M, Rothfeld J.  Papillary muscle fractional shortening is a determinant of heart shape in patients with prior myocardial infarction.  Am J Cardiol 1997;80:206-206.

Tischler M, Ashikaga T, LeWinter M.  Relation between left ventricular shape and Doppler filling parameters in patients with left ventricular dysfunction secondary to coronary artery disease.  Am J Cardiol 1995;76:553-556

Tischler M, Battle R, Saha M, Niggel J, LeWinter M. Observations suggesting a high incidence of exercise-induced  severe mitral regurgitation in patients with mild rheumatic mitral valve disease at rest.  J Am Coll Cardiol 1994;25:128-133.

Tischler M, Cooper K, Rowan M, LeWinter M. Mitral Valve Replacement Versus Mitral Valve Repair:  A Doppler and Quantitative Stress Echocardiographic Study. Circulation 1994;89:132-137.

Tischler M, Battle R, Niggel J, LeWinter M. Effects of exercise on left ventricular performance in chronic, severe mitral regurgitation:  A quantitative 2-dimensional and Doppler exercise echocardiographic study.  Am J Cardiol 1996; 77:397-402.

Battle RW, Crumb S, Tischler M. Hemodynamic characteristics of congenital aortic stenosis:  A Quantitative Stress Echocardiography Study. Am Heart J 2000;139:346-351.