Bioengineering and Mathematics
Bioengineering and Mathematics
This section provides expertise in the use of mathematical modeling and bioengineering techniques to characterize complex physiological systems ranging from those involved in intracellular signaling to the intact organism. For example, the determinants of airways hyperresponsiveness, a cardinal feature of asthma, have been elucidated in mice with the use of anatomically accurate computational models of the lung. Time-activity curves of macromolecular markers in blood have been characterized with the use of multi-compartmental modeling. The coordinated activity of the diverse components of the coagulation system has been simulated with equations describing the multiple kinetic reactions involved. These approaches allow the results of detailed physiological studies in experimental animals to be translated to the human patient, facilitating development of novel and powerful diagnostic methods and therapy. In addition to its research activities, the Bioengineering and Mathematics section provides sophisticated educational opportunities, including formal course work, for members of the Cardiovascular Research Institute.
Recent Grant Support
Grant Title: Assessment of Lung Function in Mice
Sponsor: NIH R01 HL67273
PI: Jason H.T. Bates, PhD, DSc
Grant Title: Translational Research in Lung Biology and Disease.
Sponsor: NIH NCRR P20 RR15557-01
PI: Charles G. Irvin, PhD
Grant Title: The Mechanics of Acute Lung Injury
Sponsor: NIH R01 HL075593
PI: Jason H.T. Bates, PhD, DSc
Representative Publications
J.H.T. Bates and Charles G. Irvin. Time dependence of recruitment and derecruitment in the lung: a theoretical model. J Appl Physiol 93:705-713, 2002.
H.T. Moriya, J.C.T.B. Moraes, and J.H.T. Bates. Nonlinear and frequency dependent mechanical behavior of the mouse respiratory system.” Ann Biomed Eng 31: 318-326, 2003
J.H.T. Bates and B.E. Sobel. The conceptual basis of mathematics in cardiology IV. Statistics and model fitting. Coron Art Dis 14: 267-277, 2003.
G.B. Allen and J.H.T. Bates. The dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury. J Appl Physiol 96: 293-300, 2004.
S.A. Tuck, K. Maghni, A. Poirier, G.J. Babu, M. Periasamy, J.H.T. Bates, R. Leguillette, A.-M. Lauzon. Time course of airway mechanics of the (+)insert myosin isoform knockout mouse. Am J Respir Cell Mol Biol 30: 326-332, 2004.
S. Wagers, L.K.A. Lundblad, M. Ekman, C.G. Irvin and J.H.T. Bates. The allergic mouse model of asthma: normal smooth muscle in an abnormal lung? J Appl Physiol 96: 2019-2027, 2004.
M.P. Young, H.L. Manning, D.L. Wilson, S.A. Mette, R.R. Riker, J.C. Leiter, S.K. Liu, J.H.T. Bates, and P.E. Parsons. Ventilation of patients with acute lung injury and ARDS. Crit Care Med 32: 1260-1265, 2004.
S.W. Wagers, R.J. Norton, L.M. Rinaldi, J.H.T. Bates, B.E. Sobel, and C.G. Irvin. Extravascular coagulation, fibrinolytic system proteins, and airway hyperresponsiveness. J Clin Invest 114: 104-111, 2004.
L.K.A. Lundblad, J. Thompson-Figueroa, T. Leclair, C.G. Irvin, and J.H.T. Bates. Thoracic gas volume measurements in paralyzed mice. Ann Biomed Eng . 32: 1420-1427, 2004
J.C. Cohen, M. Levitzky, L.K.A. Lundblad, J.H.T. Bates, and J.E. Larson. The "Goldilocks Effect" in Cystic Fibrosis: Identification of a Lung Phenotype in the cftr Knockout and Heterozygous Mouse. BMC Genetics. 5: 21 (6 pages), 2004.
