Jason H.T. Bates, PhD, DSc
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Jason H.T. Bates, PhD, DScEducation:Graduate School Training:ResidencyFellowshipPostdoctoral Training McGill University, Montreal, Canada Specialty:Biomedical Engineering and Certifications:Academic Appointments:Professor of Medicine and Molecular Physiology & Biophysics Biography:Dr. Bates has been a faculty member at the University of Vermont College of Medicine (Pulmonary/Critical Care Division) and a member of the Vermont Lung Center since 1999. He is also leader of the Biomedical Engineering Core of the Vermont Lung Center. Prior to being recruited to Vermont, Dr. Bates was a Professor of Medicine and Biomedical Engineering at McGill University. He currently serves on the editorial boards of two prominent journals related to the physiology of respiration, and was an associate editor for the European Respiratory Journal from 1997 to 2001. Dr. Bates was elected a Fellow of the American Institute for Medical and Biological Engineering in 2002, and has numerous other society memberships including Senior Membership in the Institute of Electrical and Electronic Engineers.Major Research Interests:Dr. Bates’ research interests are directed toward the application of mathematical modeling and engineering methodologies in biomedicine. Most of his work has been directed toward investigating the mechanical behavior of the lungs. In particular, he is interested in determining how to extract information about lung function from measurements of gas pressures and flows made at various sites in animal models and in humans. This has led to the development of a number of novel experimental methodologies for determining the mechanical impedance of the lungs, and to the identification of mathematical models of lung mechanics. A particularly notable example of this activity was the development of a computer-controlled mechanical ventilator for small laboratory animals that has been commercialized, and which allows researchers to precisely characterize pulmonary physiology in mice. Dr. Bates is currently using this device to elucidate pulmonary derangements in mouse models of asthma and acute lung injury. With the aid of micro-computed tomography, Dr. Bates is able to develop anatomically accurate computational models of the mouse lung which can then be used to interpret experimental measurements. Dr. Bates is also interested in the mathematical modeling of complex biological systems, particularly as it pertains to furthering our understanding of complex diseases. He has developed a tutorial in biomathematics for physicians and physiologists, and is currently exploring ways to expand this to deal with biological networks. He has also recently developed a computational model of electrical excitation in cardiac tissue in collaboration with cardiac electrophysiologist Dr. Peter Spector. This model is used as a teaching aid. Current Grant Support Grant Title: Assessment of Lung Function in Mice Grant Title: Translational Research in Lung Biology and Disease. Grant Title: The Mechanics of Acute Lung Injury Grant Title: Airways Hyper-Responsiveness: from Molecule to Organ
Publications:Representative Publications a Total of 225 J.H.T. Bates and Charles G. Irvin. Time dependence of recruitment and derecruitment in the lung: a theoretical model. J Appl Physiol 93: 705-713, 2002. H.T. Moriya, Moraes J.C.T.B., and Bates J.H.T. Nonlinear and frequency dependent mechanical behavior of the mouse respiratory system.” Ann Biomed Eng 31: 318-326, 2003 J.H.T. Bates and B.E. Sobel. The conceptual basis of mathematics in cardiology IV. Statistics and model fitting. Coron Artery Dis 14: 267-277, 2003. G.B. Allen and J.H.T. Bates. The dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury. J Appl Physiol 96: 293-300, 2004. S. Wagers, L.K.A. Lundblad, M. Ekman, C.G. Irvin and J.H.T. Bates. The allergic mouse model of asthma: normal smooth muscle in an abnormal lung? J Appl Physiol 96: 2019-2027, 2004. S.W. Wagers, R.J. Norton, L.M. Rinaldi, J.H.T. Bates, B.E. Sobel, and C.G. Irvin. Extravascular coagulation, fibrinolytic system proteins, and airway hyperresponsiveness. J Clin Invest 114: 104-111, 2004. G.B. Allen, T. Leclair, M. Cloutier, J. Thompson-Figueroa, and J.H. Bates. The response to recruitment worsens with progression of lung injury and fibrin accumulation in a mouse model of acid aspiration. Am J Physiol Lung Cell Mol Physiol 292:L1580-L1589, 2007. J.H.T. Bates, G.S. Davis, A. Majumdar, K.J. Butnor, and B. Suki. Linking parenchymal disease progression to changes in lung mechanical function by percolation. Am J Respir Crit Care Med 176:617-623, 2007. J.H.T. Bates, A. Cojocaru, H.C. Haverkamp, L.M. Rinaldi, and C.G. Irvin. The synergistic interactions of allerlgic lung inflammation and intra-tracheal cationic protein. Am J Respir Crit Care Med 177:261-268, 2008. |
