Marc Tischler, MD, FACC, FACP, FAHA

Education:

Training:

Residency

Fellowship

Specialty:

Certifications:

Academic Appointments:

Biography:

Dr. Tischler is the Director of the Fletcher Allen Health Care Echocardiography Laboratory and Chair of a task force to optimize care of hospitalized patients with congestive heart failure. An expert and teacher in Clinical Pharmacology, he has been an investigator in multiple multi-center trials characterizing the pharmacokinetics, pharmacodynamics and tolerability of novel treatments and combinations. His research has helped to define the role of medical and surgical therapy for patients with mitral regurgitation, a common form of valvular heart disease. Dr. Tischler has been active in many professional groups and academic committees that seek to improve medical education and the patient experience. He has published and presented frequently in medical texts, journals, and national meetings.

Major Research Interests:

Dr. Tischler's research has focused on the natural history and pathophysiology of mitral regurgitation with particular emphasis on the implications of mitral valve repair compared with valve replacement surgery.   He has studied the effects of alteration in ventricular geometry on exercise performance and ventricular filling in patients with congestive heart failure. Dr. Tischler collaborates with Dr. Ades in the study of the effects of resistance training in elderly patients with coronary disease and with Dr. LeWinter in his studies of left ventricular restoring forces.

Publications:

Representative Publications from a total of 91

Tischler M, Battle R, Saha M, Niggel J, LeWinter M. Observations suggesting a high incidence of exercise-induced  severe mitral regurgitation in patients with mild rheumatic mitral valve disease at rest.  J Am Coll Cardiol 1994; 25:128-133.

Tischler M, Cooper K, Rowen M, LeWinter M. Mitral Valve Replacement Versus Mitral Valve Repair:  A Doppler and Quantitative Stress Echocardiographic Study. Circulation 1994; 89:132-137.

Tischler M, Ashikaga T, LeWinter M.  Relation between left ventricular shape and Doppler filling parameters in patients with left ventricular dysfunction secondary to coronary artery disease.  Am J Cardiol 1995; 76:553-556.

Tischler M, Rothfeld J.  Papillary muscle fractional shortening is a determinant of heart shape in patients with prior myocardial infarction.  Am J Cardiol 1997; 80:206-206.

Tischler M, Rowen M, LeWinter M.  Effect of enalapril therapy on left ventricular mass and volumes in compensated chronic, severe mitral regurgitation. Am J Cardiol 1998; 82:242-246.

Bell S, Nyland L, Tischler M, McNabb M, Grnzier H, LeWinter M.  Alterations in the determinants of diastolic suction during pacing tachycardia. Circulation Research 2000; 87:235-240.

Tischler M, Niggel JL.  Left ventricular systolic torsion and exercise in normal hearts.  J AM SOC ECHO 2003; 16:670-674.

Mulieri L, Tischler M, Martin B, Leavitt B, Ittleman F, Alpert N, LeWinter M.  Regional differences in the force-frequency relation of human left ventricular myocardium in mitral regurgitation: Implications for left ventricular shape.  Am J Physiol 2005; 288:H2185-2191.

Ades P, Savage P, Brochu M, Tischler M, Lee M, Poehlman E. Resistance training increases total daily energy expenditure in disabled older women with coronary heart disease.  J Appl Physiol 2005; 98:1280-1285.

Tischler M, Gentchos G, White G.  Complex congenital heart disease:  A 3T CMR Perspective.  Congenital Cardiol Today 2006; 4:1-8.

Gentchos GE, Tischler MD, Christian TF.  Imaging and quantifying valvular heart disease using magnetic resonsnce techniques.  Curr Treat Options Cardiovasc Med 2006; 8:453-460.

Toth MJ, Ades PA, Tischler MD, Tracy RP, LeWinter MM.  Immune activation is associated with reduced skeletal muscle mass and physical function in chronic heart failure.  Int J Cardiol 2006; 109:179-187.