Richard E. Pratley, MD

Education:

Medical School
Wayne State University, Detroit, MI

Training:

Residency

Fellowship

University of Michigan, Ann Arbor, MI
Johns Hopkins University, Baltimore, MD
National Institute on Aging, Baltimore, MD

Specialty:

Gerontology and Geriatric Medicine
Metabolism:  Diabetes and Obesity

Certifications:

Academic Appointments:

Biography:

Dr. Pratley is Director of the Diabetes and Metabolism Translational Medicine Unit at the University of Vermont College of Medicine.  His extensive research experience in the areas of diabetes and metabolism includes the study of the effects of exercise and weight loss on energy metabolism and insulin sensitivity, and the relationship between insulin resistance and obesity.  As Head of the Diabetes and Metabolism Unit of the NIH’s Clinical Diabetes and Nutrition Section in Phoenix, Arizona, he performed important research that elucidated the nature of and mechanisms underlying diabetes and obesity in the Pima Indians.  He and his wife, Beverly, live in Jericho and have two grown children.

Major Research Interests:

Dr. Pratley has led many large-scale investigations including NIH- and industry-sponsored studies and has been recognized as the recipient of prestigious awards for his clinical research, including the Henry Christian Award for Excellence in Clinical Research.  His current research interests include the development of new drugs to treat and prevent diabetes and its complications, and understanding the role of the fat cell in increasing the risk for diabetes and heart disease.  He has published and lectured extensively, written numerous chapters on the etiology and management of type 2 diabetes, and serves as a member of the editorial board of Diabetes Care, Current Diabetes Reports, Coronary Artery Disease and as an ad hoc reviewer for many professional journals.

Recent Grant Support

NIH: (U01 HL61744) “Bypass Angioplasty Revascularization Investigation II - Diabetes” 9/00 - 9/09
Kathryn Detre, Principal Investigator, Pratley, Co-Investigator

NIH-COBRE: (P20 RR01557) Project 1 of 5 in the "Program Project Grant: Obesity and Asthma"
7/05 - 4/10
Charles Irvin, Principal Investigator, Pratley, Co-Investigator

NIH:  (R21 DK 080386) "Impaired Adipogenesis in Insulin Resistance: Pilot Clinical and in vitro Studies"
12/07 - 11/09
Richard Pratley, Principal Investigator

Publications:

Representative Publications from a Total of 133

Weyer C, Wolford JK, Hanson RL, Foley JE, Tataranni PA, Bogardus C, Pratley RE. Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21-q23 and is associated with a common polymorphism in LMNA in Pima Indians. Mol Genet Metab 2001; 72:231-238.

Pratley RE, Weyer C. The role of impaired early insulin secretion in the pathogenesis of type 2 diabetes mellitus.  Diabetologia 2001; 44:929-945.

Weyer C, Hanson K, Bogardus C, Pratley RE. Long-term changes in insulin action and insulin secretion associated with weight gain, loss, regain and maintenance of body weight. Diabetologia 2000; 43:36-46.

Weyer C, Foley JE, Bogardus C, Tataranni PA, Pratley RE.  Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance. Diabetologia 2000; 43:1498-1506.

Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999; 104:787-794.

Pratley RE, Thompson DB, Prochazka M, Baier L, Mott D, Ravussin E, Sakul H, Ehm MG, Burns DK, Foroud T, Garvey WT, Hanson RL, Knowler WC, Bennett PH, Bogardus C.  An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J Clin Invest 1998; 101:1757-1764.

Pratley  RE, Schweizer A, Rosenstock J, Foley JE, Banerji MA, Pi-Sunyer FX, Mills D, Dejager S.  Robust improvements in fasting and prandial measures of beta-cell function with vildagliptin in drug-naive patients: analysis of pooled vildagliptin monotherapy database.  Diabetes Obes Metab, E-pub Dec 17, 2007.

Lee, YH, Tharp WG, Maple R, Nair S, Permana PA, Pratley RE.  Amyloid precursor protein expression is upregulated in obesity.  Obesity (Silver Spring) 2008; 16:1493-1500.

Tharp WG, Lee YH, Maple R, Pratley RE.  The cannabinoid CB1 receptor is expressed in pancreatic delta-cells.  Biochem Biophys Res Commun 2008; 372:595-600.

Pratley RE, Matfin G.  Pre-diabetes: Clinical relevance and therapeutic approach.  Brit J Diab Vasc Dis 2008; 7:120-129.