Kenneth G. Mann, PhD

Education:

Graduate School
University of Iowa, Iowa City, IA; Biochemistry

Training:

Residency

Fellowship

Postdoctoral Fellowship
Duke University, Durham, NC

Specialty:

Certifications:

Academic Appointments:

Biography:

Dr. Mann, formerly Chairman of the Department of Biochemistry at the University of Vermont, began his research with a description of multiple forms of thrombin in 1968 that culminated in 2002 with the description of the dynamics of the process of blood coagulation in profound detail presented as the E. Donnall Thomas Lecture at the 2002 American Society of Hematology National Meeting.  In the course of his research career he has identified and described the chemical mechanisms involved in the formation of procoagulant complexes on membranes, the biophysical properties of pro- and anticoagulants, and their mechanisms of action.

In the past ten years, his laboratory has developed models for studying the entire blood coagulation process under physiologic conditions to provide a consistent description of the evolution and expression of thrombin activity in pro and anticoagulant processes.  These models include the use of synthetic plasma incorporating all the known pro- and anticoagulants in purified form, numerical-computer models based upon biophysical parameters characterized and the natural concentrations of components involved in thrombin generation process and whole blood activated purely by the tissue factor mechanism and studies of blood exuding from microvascular wounds.  These models have been used to accurately delineate the biology and biochemistry of the dynamics of thrombin formation under normal conditions and in diverse conditions including hemophilia, thrombophilia, pharmacologic interventions, exposure to anti-inflammatory agents, cholesterol suppressing agents and anticoagulant and antihemorrhagic drugs. 

The most recent studies describe the influences of common genetic polymorphisms in combination with drug interventions.  The work has contributed to improved diagnosis, prophylaxis, treatment of thrombotic and hemorrhagic diseases.  Dr. Mann has also been recipient of the Stratton Medal from the American Society of Hematology, the Grant Medal fro the International Society of Hemostasis and Thrombosis, and the Sherry Award from the American Heart Association.

Major Research Interests:

Current Grant Support

Grant Title:         Primary  Structure of Prothrombin
Sponsor:            NIH R01 HL34575/20-24
PI:                     Kenneth G. Mann

Grant Title:         Surface Dependent Reactions in Thrombosis & Thrombolysis
Sponsor:            NIH PHS HL46703/16-20
PI:                     Kenneth G. Mann

Grant Title:         Hemostasis & Thrombosis Program for Trainees
Sponsor:            NIH T31 HL07594-22
PI:                     Kenneth G. Mann

Grant Title:        Quantitative Evaluation of Factor VIII in Factor VIII Products
Sponsor:            Baxter Health Care Corporation
PI:                     Kenneth G. Mann

Grant Title:         Sponsored Research Agreement for Rivaroxaban
Sponsor:            Johnson and Johnson
PI:                     Kenneth G. Mann

Grant Title:         Human Factor V Mutants
Sponsor:            Crucel
PI:                     Kenneth G. Mann

Publications:

Recent Representative Work (of 474 Publications and 17 Patents)

Hockin MF, Jones KC, Everse SJ and Mann KG: A Model for Stoichiometric Regulation of  Blood Coagulation.  J. Biol. Chem. 277:18322-18333, 2002.

Brummel KE, Paradis SG, Butenas S and Mann KG: Thrombin functions during tissue-factor-induced blood coagulation. Blood, 100: 148-152, 2002.

Mann KG and Kalafatis M: Factor V: a combination of Dr. Jekyll and Mr. Hyde. Blood, 101: 1-11  January 2003.

Butenas S, Brummel KE, Paradis SG, and Mann KG: Influence of Factor VIIa and Phospholipids on Coagulation in “Acquired” Hemophilia.  Arteroscler. Thromb. Vasc. Biol. 23:123-129, 2003.

Butenas S, Dee JD, and Mann KG:  The function of factor XI in tissue factor-initiated thrombin generation.  J. Thromb. Haemost. 1:2103-2111, 2003.

Brummel-Ziedins KE, Pouliot RL, and Mann KG:  Thrombin generation: Phenotypic quantitation.  J. Thromb. Haemost. 2:281-288, 2004.

Mann KG, Brummel-Ziedins K, Undas A, and Butenas S:  Does the genotype predict the phenotype? Evaluations of the  hemostatic preteome.  J. Thromb. Haemost. 2:1727-1734, 2004.

Orfeo T, Butenas S, Brummel-Ziedins KE, and Mann KG:  The tissue factor requirement in blood coagulation.  J. Biol. Chem. 280:42887-42896, 2005.

Butenas S, Orfeo T, Kalafatis M, and Mann KG:  Peptidomimetic inhibitors for activated protein C: implications for hemophilia management.  J. Thromb. Haemost. 4:2411-2416, 2006.

Undas A, Brummel-Ziedins KE, and Mann KG:  Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions.  Blood 109:2285-2292, 2007.